File Extension Library

.SMILES File Extension

  • Category: Various data Files

What is an .SMILES file?

.SMILES file extension has been classified as Various data Files.

.SMILES is SMILES chemical modeller input

The smiles file extension is related to SMILES, a simple yet comprehensive chemical language in which molecules and reactions can be specified using ASCII characters representing atom and bond symbols. SMILES contains the same information as is found in an extended connection table but with several advantages.

A SMILES string is human understandable, very compact, and if canonicalized represents a unique string that can be used as a universal identifier for a specific chemical structure. In addition, a chemically correct and comprehensible depiction can be made from any SMILES string symbolizing either a molecule or reaction.

SMILES development was initiated by David Weininger in the late 1980s using the concept of a graph with nodes as atoms and edges as bonds to represent a molecule. Parentheses are used to indicate branching points and numeric labels designate ring connection points. The basic SMILES grammar also includes as well as isotopic information, configuration about double bonds, and chirality leading to what is known as isomeric SMILES.

MIME types:

.SMILES file format is deprecated and this file format is no longer supported.

Currently, .SMILES file type is not actively used and is obsolete. This usually happens with system files in older operating systems, files from long-discontinued software, or with previous versions of some file types (documents, projects, images, etc.) that were replaced in later versions of the original programs.

How to open:

This file type is not meant to be opened directly, there is no software that could open and work with it directly, or there is no information available in public sources about opening this file type. This is usually the case of some internal data files, caches, temporary files etc.

How to convert:

As far as we know, this .smiles file type can't be converted to any other file format. This is usually the case of system, configuration, temporary, or data files containing data exclusive to only one software and used for its own purposes. Also some proprietary or closed file formats cannot be converted to more common file types in order to protect the intellectual property of the developer, which is for example the case of some DRM-protected multimedia files.

How to Open .SMILES file on different platforms

Open .SMILES File on Windows

  • Right-click a .SMILES
  • Left-click "Open With" > "Choose another app"
  • Select the program that opens .SMILES file and Select check box "Always use this app to open .SMILES files" Press "Ok"

Open .SMILES File on Mac

  • Right-click (or Ctrl + Left-click) the .SMILES file
  • Click "Open With" > "Other.."
  • Then choose another program from the app list and press "Open"
  • Select check box "Turn on" for "Always open in app"

Open .SMILES File on Linux

Right click on the .SMILES file, choose "Open with" and select a program from the list above

Open .SMILES File on iPhone

Select a file. If you don't see an application to open the .SMILES file, tap "Share" and choose the right app.
Method 2
Save the file. Then open the app «Files». Touch and hold the file, then release your finger. You will see a black menu bar. After that tap "Share" and select an application.

Open .SMILES File on Android

Tap the Settings icon on an Android smartphone, then select «Applications». Click the Settings icon in the upper right corner of the screen, to change the default apps.
If you want to open, edit, save or even convert .SMILES files on Android, then your best bet is to download one of the dedicated apps available on Google Play.

How to fix problems with .SMILES files

  1. You need to update the application that you normally use to open .SMILES files. Only the latest version of the software supports the current .SMILES file format
  2. You need to check the .SMILES file for viruses. To do this, you need to scan it with a popular antivirus (Norton, Nod32, Kaspersky, Dr.Web, etc.)